Case
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Diagnosis: Mixed Epithelial and Stromal Tumor of the kidney
Mixed Epithelial and Stromal Tumor of the kidney (MESTK) is a benign tumor that was included in the WHO 2004 renal tumor classification. It is a rare and distinctive kidney tumor composed of both epithelium and stroma with solid and cystic architecture. MESTK occurs predominantly in middle-aged peri-menopausal women and older women, especially those with a history of estrogen therapy, which indicates an underlying association between estrogen and MESTK. However, there are some rare male or pediatric cases. The tumor was first identified by Michal and Syrucek in 1998 and has been also termed ‘cystic hamartoma of the renal pelvis,’ ‘adult mesoblastic nephroma,’ ‘cystic nephroma,’ ‘mature nephroblastic tumor’ or ‘cystic partially differentiated nephroblastoma.
Go to the chapter: Neoplasms, of our Tutorial (this chapter has only Spanish version).
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References
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Wang CJ, Lin YW, Xiang H, Fang DB, Jiang P, Shen BH. Mixed epithelial and stromal tumor of the kidney: report of eight cases and literature review. World J Surg Oncol. 2013;11(1):207. [PubMed link] [Free full text]
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Lopez-Fontana G, Gallegos I, Sepúlveda F, Bonomo JI, Castillo OA. Mixed epithelial and stromal tumor of the kidney (MEST). Arch Esp Urol. 2012;65(7):713-6. [PubMed link]
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Moslemi MK. Mixed epithelial and stromal tumor of the kidney or adult mesoblastic nephroma: an update. Urol J. 2010;7(3):141-7. [PubMed link] [Free full text]
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Lane BR, Campbell SC, Remer EM, Fergany AF, Williams SB, Novick AC, Weight CJ, Magi-Galluzzi C, Zhou M. Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics. Urology. 2008;71(6):1142-8. [PubMed link]