Haring CM, Rietveld A, van den Brand JA, Berden JH. Segmental and Global Subclasses of Class IV Lupus Nephritis Have Similar Renal Outcomes. J Am Soc Nephrol. 2012 Jan;23(1):149-54. [PubMed link]
This meta-analysis did not support a significant difference in renal outcome between the segmental (IV-S) and global (IV-G) subclasses.

de Freitas DG, Sellarés J, Mengel M, Chang J, Hidalgo LG, Famulski KS, Sis B, Einecke G, Halloran PF. The Nature of Biopsies with "Borderline Rejection" and Prospects for Eliminating This Category. Am J Transplant. 2011 Jan;12(1):191-201. [PubMed link]
"Decision tree analysis showed that i-total >27% and tubulitis extent >3% match the molecular diagnosis of TCMR in 85% of cases". However, the authors inform that "most cases designated borderline by histopathology are found to be nonrejection by molecular phenotyping".

Sethi S, Nester CM, Smith RJ. Membranoproliferative glomerulonephritis and C3 glomerulopathy: resolving the confusion. Kidney Int. 2011 Dec 7. doi: 10.1038/ki.2011.399. [Epub ahead of print] [PubMed link]
Subgrouping of MPGN has led to unnecessary confusion, primarily because immunoglobulin-negative MPGN I and MPGN III are more common than once recognized. Together with MPGN II, which is now called dense deposit disease, immunoglobulin-negative, C3-positive glomerular diseases fall under the umbrella of C3 glomerulopathies (C3G). An very interesting paper.

Snanoudj R, Royal V, Elie C, Rabant M, Girardin C, Morelon E, Kreis H, Fournet JC, Noël LH, Legendre C. Specificity of Histological Markers of Long-Term CNI Nephrotoxicity in Kidney-Transplant Recipients Under Low-Dose Cyclosporine Therapy. Am J Transplant. 2011 Dec;11(12):2635-46. [PubMed link]
This comparative 10-year study in kidney transplant recipients treated with or without cyclosporine shows that all of the chronic elementary histological lesions, including muscular arteriolar hyalinosis, progressed in frequency and severity in both groups.

Mengel M, Mihatsch M, Halloran PF. Histological characteristics of calcineurin inhibitor toxicity-there is no such thing as specificity! Am J Transplant. 2011 Dec;11(12):2549-50. [PubMed link] [Free full text]
"There is no such thing as a specific histological diagnosis of CNIT in an individual patient. The diagnosis of probable CNIT is one of exclusion.".An interesting editorial.

Zhou FD, Shen HY, Chen M, Liu G, Zou WZ, Zhao MH, Wang HY. The renal histopathological spectrum of patients with nephrotic syndrome: an analysis of 1523 patients in a single Chinese centre. Nephrol Dial Transplant. 2011 Dec;26(12):3993-7. [PubMed link]
Minimal change disease, lupus nephritis and idiopathic membarnous GN were the main cause of nephrotic syndrome among younger patients, and membranous GN was the main cause of nephrotic syndrome among older patients.

Floege J. The pathogenesis of IgA nephropathy: what is new and how does it change therapeutic approaches? Am J Kidney Dis. 2011 Dec;58(6):992-1004. [PubMed link]
A review.

Larsen CP, Bell JM, Harris AA, Messias NC, Wang YH, Walker PD. The morphologic spectrum and clinical significance of light chain proximal tubulopathy with and without crystal formation. Mod Pathol. 2011 Nov;24(11):1462-9. [PubMed link]
The authors describe 10 cases of light chain proximal tubulopathy without crystal deposition and 3 cases of light chain proximal tubulopathy with crystals.

Waikhom R, Sarkar D, Patil K, Pandey R, Dasgupta S, Jadhav J, Abraham A. Non-IgA mesangioproliferative glomerulonephritis: a benign entity? Nephrol Dial Transplant. 2011 Nov 29. [Epub ahead of print] [PubMed link]
Mesangioproliferative glomerulonephritis without IgA deposits is not well described in the literature, and it appears to be prevalent mainly in the developing countries. A series of 57 patients.

Jefferson JA, Alpers CE, Shankland SJ. Podocyte biology for the bedside. Am J Kidney Dis. 2011 Nov;58(5):835-45. [PubMed link]
This review focus on recent advances and implications for translating this biology into therapy.

Yau T, Korbet SM, Schwartz MM, Cimbaluk DJ. The Oxford Classification of IgA Nephropathy: A Retrospective Analysis. Am J Nephrol. 2011 Sep 28;34(5):435-444. [PubMed link]
A retrospective study of 54 patients. Te authors conclude: "the degree of tubulointerstitial fibrosis was the only feature independently predictive of outcome".

Jefferson JA, Nelson PJ, Najafian B, Shankland SJ. Podocyte disorders: core curriculum 2011. Am J Kidney Dis. 2011 Oct;58(4):666-77. [PubMed link] [Free full text]

Suzuki H, Kiryluk K, Novak J, Moldoveanu Z, Herr AB, Renfrow MB, Wyatt RJ, Scolari F, Mestecky J, Gharavi AG, Julian BA. The pathophysiology of IgA nephropathy. J Am Soc Nephrol. 2011 Oct;22(10):1795-803. [PubMed link]
At least four processes would contribute to development of IgA nephropathy: a genetically determined increase in circulating levels of IgA1 with galactose-deficient O-glycans; synthesis and binding of antibodies directed against galactose-deficient IgA1; formation of immune complexes that accumulate in the mesangium; and activation of mesangial cells, inducing proliferation and secretion of extracellular matrix, cytokines, and chemokines.

Basford AW, Lewis J, Dwyer JP, Fogo AB. Membranous nephropathy with crescents. J Am Soc Nephrol. 2011 Oct;22(10):1804-8. [PubMed link]
A brief review based on a case presentation.

Debiec H, Martin L, Jouanneau C, Dautin G, Mesnard L, Rondeau E, Mousson C, Ronco P. Autoantibodies Specific for the Phospholipase A(2) Receptor in Recurrent and De Novo Membranous Nephropathy. Am J Transplant. 2011 Oct;11(10):2144-52. [PubMed link]
The authors found that PLA(2) R1 was involved in 5 of 10 patients with recurrent MN, but in none of 9 patients with de novo MN, and that some patients with PLA(2) R1-related idiopathic MN and anti-PLA(2) R1 antibodies at the time of transplantation did not develop recurrence.

Moore JL, Neilson EG, Siegel V; on behalf of the Associate Editors at the Journal of the American Society of Nephrology. Effect of Recommendations from Reviewers Suggested or Excluded by Authors. J Am Soc Nephrol. 2011 Sept;22(9):1598-602. [PubMed link]
The Journal of the American Society of Nephrology (JASN) gives authors submitting original research the option of suggesting qualified reviewers or those they wish to exclude. Author-suggested reviewers, as a group, make more positive recommendations than editor-suggested reviewers (P = 0.01). Author-excluded reviewers impart significantly more negative recommendations than other reviewers of the same manuscript (P = 0.029).

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